Understanding the Science of Acupuncture


Understanding the Science of Acupuncture



Acupuncture is a traditional Chinese technique that has been used throughout history to treat a number of health problems associated with inflammation. It also assists with the pain related to these conditions. Considering the extent to which this treatment has been used, it may surprise you to know that the scientific basis of the technique remains widely and poorly understood. One of the big questions surrounding this complementary medical practice is, ‘What is the neuroanatomical basis for body region, or acupoint, selectivity?’ 

As such, we are delighted to announce that a recent study has uncovered a subset of neurons that must be present for acupuncture to trigger an anti-inflammatory response via a specific signalling pathway. The study also revealed that these neurons occur in the hindlimb but not in the abdomen, thus explaining the differential response to acupuncture.

It is the research teams aim to better understand the underlying neuroanatomy of acupuncture to help improve and refine the technique across the board.

The team, led by neuroscientists at Harvard Medical School has elucidated the underlying neuroanatomy of acupuncture that activates a specific signalling pathway.

This study published in October identified a subset of neurons that must be present for acupuncture to trigger an anti-inflammatory response via this signalling pathway. The scientists determined that these neurons occur only in a specific area of the hindlimb region—thus explaining why acupuncture in the hindlimb works, while acupuncture in the abdomen does not.

One area of particular interest to the research team is the so-called cytokine storm—the rapid release of large quantities of cytokines that frequently drives severe, systemic inflammation, and can be triggered by many things, including COVID-19, cancer treatment, or sepsis.

“This exuberant immune response is a major medical problem with a very high fatality rate of 15% to 30%,” said lead investigator Qiufu Ma, HMS professor of neurobiology at Dana-Farber Cancer Institute.

In recent decades, acupuncture has been increasingly embraced in Western medicine as a potential treatment for inflammation. In this technique, acupoints on the body’s surface are mechanically stimulated, triggering nerve signalling that affects the function of other parts of the body, including organs.

In a 2014 study, researchers reported that electroacupuncture, a modern version of traditional acupuncture that uses electrical stimulation, could reduce cytokine storm in mice by activating the vagal-adrenal axis—a pathway wherein the vagus nerve signals the adrenal glands to release dopamine. In a study published in 2020, Ma and his team discovered that this electroacupuncture effect was region-specific: It was effective when given in the hindlimb region, but did not have an effect when administered in the abdominal region. The team hypothesized that there may be sensory neurons unique to the hindlimb region responsible for this difference in response.

Within their latest study, the researchers conducted a series of experiments in to investigate this hypothesis. They identified a small subset of sensory neurons marked by expression of the PROKR2Cre receptor. They determined that these neurons were three to four times more numerous in the deep fascia tissue of the hindlimb than in the fascia of the abdomen. Then the team created mice that were missing these sensory neurons. The team discovered that electroacupuncture in the hindlimb did not activate the vagal-adrenal axis in these mice. 

In a second experiment, the team used light-based stimulation to directly target these sensory neurons in the deep fascia of the hindlimb. This stimulation activated the vagal-adrenal axis in a manner similar to electroacupuncture. 

Finally, the team explored the distribution of the neurons in the hindlimb. They discovered that there are considerably more neurons in the anterior muscles of the hindlimb than in the posterior muscles, resulting in a stronger response to electroacupuncture in the anterior region. “Based on this nerve fibre distribution, we can almost precisely predict where electrical stimulation will be effective and where it will not be effective,” Ma explained.

Ma has said “this is the first concrete, neuroanatomic explanation for acupoint selectivity and specificity. They tell us the acupuncture parameters, so where to go, how deep to go, how strong the intensity should be.” 

The next step will be clinical testing of electroacupuncture in humans with inflammation caused by real-world infections such as COVID-19. 

“We have a lot of tough chronic diseases that still need better treatments,” Ma explained, “such as inflammatory bowel syndrome and arthritis”. 

Ma hopes that his research will ultimately advance the scientific understanding of acupuncture and provide practical information that can be used to improve and refine the technique.




The work was primarily supported by the National Institutes of Health (grant R01AT010629), and partially supported by Harvard/MIT Joint Research Grants Program in Basic Neuroscience and the Wellcome Trust (grant 200183/Z/15/Z). For further information on salary support for the researchers, please refer to the paper.

The DOI for this paper is 10.1038/s41586-021-04001-4

The paper is available at the following URL: 



Open Access Published: October 11, 2021, DOI:https://doi.org/10.1016/j.cell.2021.09.023

Sourced originally through Newswise

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