Researchers discover biomarks of ALS in teeth

 

Researchers discover biomarks of ALS in teeth

 

Mount Sinai scientists have identified biological markers present in childhood that relate to the degenerative and often fatal neurological disease called amyotrophic lateral sclerosis, also known as ALS or Lou Gehrig’s disease, according to a study published in the Annals of Clinical and Translational Neurology in May.

The researchers found the markers in the teeth of patients who went on to develop ALS as adults. They used lasers to map growth rings that form daily in the teeth and discovered evidence in the growth rings formed at birth and within the first 10 years of life that patients with ALS metabolized metals differently than patients without the disease.

ALS is a condition that usually manifests when someone is in their 50s or 60s. The cause is not known, and there is no test to predict its onset. Genetic studies have not revealed a great deal yet, and while experts believe environmental factors play a significant role in the development of the disease, there have been no clear indications of which ones.

“This is the first study to show a clear signature at birth and within the first decade of life, well before any clinical signs or symptoms of the disease,” said senior author Manish Arora, BDS, MPH, PhD, Edith J. Baerwald Professor and Vice Chair of Environmental Medicine and Public Health at the Icahn School of Medicine at Mount Sinai. “We hope in the long term, after validation of this work in larger studies, that this will lead to preventive strategies. What’s exciting about this work is that we are looking at biological pathways that we could potentially modify with drug development.”

The study showed dysregulated uptake of a mixture of essential elements, including zinc and copper, as well as toxins like lead and tin, in 36 ALS patients compared to 31 controls. The markers of metal uptake dysregulation were also observed in teeth from an ALS mouse model that also showed differences in the distribution of metals in the brain compared to controls.

“Our previous work showed that the dysregulation of elemental metabolism in early life was associated with the onset of neurological disease such as autism and ADHD,” said Christine Austin, PhD, Assistant Professor of Environmental Medicine and Public Health at the Icahn School of Medicine at Mount Sinai, a major contributor to this work. “This study shows that metabolic dysregulation is also associated with neurological conditions with a much greater lag to symptom onset”.

Loneliness and hunger share a home in the brain

Loneliness and hunger share a home in the brain

A new study has discovered that the same part of the brain is
involved in craving company and craving food. This supports

Why are men so negatively impacted by depression?

Potential link found between red meat consumption and women’s mental health

News

A January 13 2021 article in the British Medical Journal; ‘Supportive & Palliative Care’ described a metanalysis of a number of trials and database searches, which looked at the use of acupuncture as used for the treatment of pain in cancer cases.

The following study was published in the journal ‘Holistic Nurse Practitioner’ - 2020 Dec 9th – showing that reflexology was helpful to operating room nurses experiencing low back pain.

In a huge breakthrough for complementary medicine, a conventional health journal, The Oncologist, has published a study on how homeopathic medicine has a significant effect on a type of lung cancer.

Loneliness can be defined in a number of ways, but most specialists agree that it is an undesirable and hurtful emotion, and can impact both physical and mental wellbeing.

The COMPLEMENTARY MEDICAL ASSOCIATION (The CMA) © 2012. No part of this site may be reproduced without the express permission of The Complementary Medical Association. If used without prior consent a charge of US $1,000 per article, or mini section is paid (US $50 per word (minimum) will be charged. This is not meant to reflect a commercial rate for the content, but as a punitive cost and to reimburse The CMA for legal fees and time costs). Use of the contents, without permission will be taken as consent to bill the illegal user in full.